The higher BSI Global Score in those with acute PTH at Week 1 included higher subscale scores in (i) Anxiety (p < 0.0001), mean 55.1 (11.2 SD 95%CI 53.6–56.6) vs a mean of 46.4 (7 SD, 95% CI 43.1–49.6]), (ii) Somatic (p = 0.0019), mean 57.5 (9.3 SD, 95%CI 56.3–58.8) vs mean of 51.4 (7.4 SD 95% CI 47.9–54.8), and (iii) Depression (p = 0.005), mean 53.4 (SD10.4 95%CI 52–54.8) vs mean of 46.6 (7.6 SD 95%CI 43–50.2). Here, PTH is linked to major depressive disorder.