The GRACE score, which was widely used as a risk prediction tool in patients with ACS, was positively correlated with diabetes (p = 0.001), age (p < 0.001), Ln-FPG (p = 0.007), Ln-sclerostin (p = 0.019), and Ln-OPG (p < 0.001), and negatively correlated with BMI (p = 0.018), LDL-C (p = 0.003), Ln-TG (p < 0.001) and eGFR (p < 0.001) in univariate linear regression analysis. The gene discussed is SOST; the disease is diabetes mellitus.