Other strategies to improve seroconversion may be the choice of an alternative treatment if available (i.e. TPO-RA versus rituximab in ITP), vaccinating before B-cell depleting drugs, and allowing enough time for immune reconstitution in patients treated with B-cell depleting agents, as already suggested for lymphoproliferative disorders20,21. Here, TPO is linked to autoimmune thrombocytopenic purpura.