CDKN2A and type 2 diabetes mellitus: Although p14ARF, p16INK4A and p15INK4B play multiple biological roles in mouse and human β-cells11 and were widely assumed to mediate the T2D risk transmitted by risk-SNPs at this locus, a study we performed analyzing CDKN2A/B risk-SNP impact on human islets showed a stronger association with ANRIL than with the protein-coding genes12.