HNSCC patients with higher expression of ANG-2 (p = 0.74), bFGF (p = 0.32), HGF (p = 0.22), VEGF (p = 0.97), PDGF-BB (p = 0.27), MMP-2 (p = 0.83), MMP-10 (p = 0.42), MMP-13 (p = 0.61), and TIMP-2 (p = 0.9) showed higher 5 years survival rate compared to those HNSCC patients with higher expressions of these factors but there was no significant difference between lower and higher expression groups (Fig. 8B, Fig. 8C, Fig. 8E, Fig. 8G, Fig. 8I, Fig. 8K, Fig. 8O, Fig. 8P, Fig. 8R). Here, MMP13 is linked to head and neck squamous cell carcinoma.