Similarly, HNSCC patients with lower expressions of ANG (p = 0.15), Leptin (p = 0.64), PIGF (p = 0.089), MMP- MMP-1 (p = 0.35), MMP-3 (p = 0.28), MMP-8 (p = 0.1), and MMP-9 (p = 0.54) showed higher 5 years survival rate compared to those HNSCC patients with higher expressions of these factors but there was no significant difference between lower and higher expression groups (Fig. 8A, Fig. 8F, Fig. 8H, Fig. 8J, Fig. 8L-Fig. 8N). The gene discussed is ANG; the disease is head and neck squamous cell carcinoma.