HNSCC patients with higher expression of ANG-2 (p = 0.74), bFGF (p = 0.32), HGF (p = 0.22), VEGF (p = 0.97), PDGF-BB (p = 0.27), MMP-2 (p = 0.83), MMP-10 (p = 0.42), MMP-13 (p = 0.61), and TIMP-2 (p = 0.9) showed higher 5 years survival rate compared to those HNSCC patients with higher expressions of these factors but there was no significant difference between lower and higher expression groups (Fig. 8B, Fig. 8C, Fig. 8E, Fig. 8G, Fig. 8I, Fig. 8K, Fig. 8O, Fig. 8P, Fig. 8R). This evidence concerns the gene MMP2 and head and neck squamous cell carcinoma.