We next observed that “low” and “high” FBL-related breast cancer groups seemed to exhibit the same pattern of OS and DFS in specific breast cancer subtypes, including in ER + PR ± HER2- (corresponding to luminal subtype, P = 0.2485 and 0.2358, respectively) and in ER- PR- HER2- (corresponding to triple negative subtype, P = 0.0441 and 0.0323, respectively) (data not shown). This evidence concerns the gene ESR1 and breast cancer.