This function supports the observation in pancreatic ductal adenocarcinoma that TFEB promotes the endocytosis of α5β1 integrin and the disassembly focal adhesion by modulating RAB5 and in hepatocellular carcinoma the degradation of β1 integrin by activating lysosome machinery [74, 75]. This evidence concerns the gene RAB5A and hepatocellular carcinoma.