These two SNPs were found to be associated with the methylation status of respectively cg08452456, exonic to TBKBP1, and cg12183861, localized in the 5’UTR of TBKBP1. Interestingly enough, rs8070463 SNP has been previously associated with ankylosing spondylitis, a rare autoimmune condition [31]. The gene discussed is TBKBP1; the disease is ankylosing spondylitis.