INS and Insulin resistance: Compared to non-MOD participants they had also larger improvement in insulin resistance (HOMA2-IR; mean difference −0.6 [95% CI −1.1 to −0.1]) and ameliorated insulin secretion (HOMA2-B; 16.8 [95% CI 6.5 to 26.9]), while the average change of body weight was −1.5 kg (95% CI −3.2 to 0.1; non-significant).