MAPT and Alzheimer disease: In HC subjects, LMM for time-varying CSF p-tau/Aβ showed that GRS-AD and time-varying αSyn were significantly associated with time-varying CSF p-tau/Aβ, suggesting that higher GRS-AD was associated with higher CSF p-tau/Aβ and time-varying CSF αSyn positively correlates with time-varying CSF p-tau/Aβ.