HTR2C and Cachexia: Other animal models for anorexia support the involvement of 5HT2C in rats’ decreased food intake: injected rats with LPS (Kopf et al., 2010), those subjected to high activity schedules (activity-based anorexia; Rieg and Aravich, 1994), or in rats subjected to a paradigm of cachexia (Ezeoke and Morley, 2015).