Analysis of GFP-positive stromal cells isolated by fluorescence-activated cell sorting (FACS) showed reduced Sqstm1 (coding for p62) mRNA levels in stromal cells on incubation with tumor cells, which also correlated with an increase in bona fide CAF markers, such as Tgfb1 and Sdf-1 (Figure 1A). The gene discussed is CXCL12; the disease is neoplasm.