Moreover, as there were higher levels of CRP, arterial lactate, and RDW, in parallel with lower arterial bicarbonate, PaO2/FiO2 ratio, platelets, and Hgb concentration in patients with sepsis and AKI,(7,8,17) it can be assumed that when inflammation occurs, it reduces iron metabolism, and bone marrow function is inhibited, thus, the erythrocyte proliferation and maturation are inhibited,(29,30) leading to increased RDW values and anemia,(31) while inflammatory dysregulation can reduce tissue perfusion and thus cause AKI. The gene discussed is CRP; the disease is anemia.