Moreover, patients with CD4 count < 100 cells/μL are at highest risk of suffering of meningitis, suggesting that there is an urgent need of rapid rollout of Cryptococcal Antigen (CrAg) Lateral Flow Assay in Mozambique for early detection of Cryptococcus neoformans, in order to improve the outcome of HIV infected patients in Mozambique. This evidence concerns the gene CD4 and infectious meningitis.