The studies included in this review that analysed the participants by quartiles report a dose-response relationship between SB and biomarkers and independent associations with SB only for high duration of sedentary time: Lynch et al. [54] reported significant associations between SB, fasting insulin and HOMA-R for more than 8.8 hours/day of SB; Healy et al. [48] found a cut-off of 7.24 hours/day of SB that increase fasting insulin; Honda et al. [29] found that more than 10 hours/day of SB significantly increase the OR of insulin resistance and diabetes. Here, INS is linked to diabetes mellitus.