SRRM4 and autosomal dominant centronuclear myopathy: However, these BIN1-specific regulatory events are critically important: inclusion of BIN1 exon 7 in skeletal muscle is associated with centronuclear myopathy in myotonic dystrophy patients (98), and functions in controlling endocytosis via promoting an interaction with Dnm2 in neural cells, where it is positively regulated by SRRM4 (82).