CXCL10 is known to stimulate the activation and migration of immune cells, such as monocytes, NK-cells, and T cells to the site of infection.30 Corroborating these data, NK markers (NCAM1), T-cell subsets markers (ie, CD8A, CD3E, IL7R, and CD4), and cytotoxicity markers (ie, GNLY and GZMA) were all downregulated in blood at the peak of the response, probably reflecting lymphocyte migration or marginalisation out of peripheral blood, as previously reported,18,19,31 whereas myeloid-associated genes (ie, CD14 and CD163) were transiently upregulated. Here, CD3E is linked to infection.