In contrast to the European genome-wide association study, we observed no significant association (P < 5e−8) between variants in the MHC region (imputed 175 classic class I and II HLA alleles) and breast cancer risk in our Asian study of 12,901 breast cancer cases and 12,583 controls (smallest P = 1.08e−3, HLA-C*12:03) [5]. This evidence concerns the gene HLA-C and breast carcinoma.