Contrary to this, alleles from MHC class II sub-region were found to be associated with breast cancer risk in studies on populations of European ancestry (HLA-DQB1*03 [20], HLA-DRB1*10:01 [21] HLA-DRB1*11:01 [21], and HLA-DRB1*13 [20]) and Middle-Eastern populations (HLA-DQB1*02 [14, 22, 23], HLA-DRB1*03 [22], HLA-DQB1*06 [22], HLA-DRB1*07 [14], HLA-DRB1*12 [24], HLA-DRB1*13 [22], and HLA-DRB1*18:01 [25]) populations. The gene discussed is HLA-DRB1; the disease is breast cancer.