MADCAM1 and colitis: In a previously published study on dextran sodium sulphate (DSS)-induced colitis, Soriano, A. et al. demonstrated the functional role of VCAM1 as a mediator of leukocyte adhesion in colitis and a potent therapeutic effect on immunoneutralisation as compared to MAdCAM-1 and intercellular adhesion molecule 1 (ICAM-1) [43].