Tubular adenocarcinoma with HER2 score of 3 + was identified by pathological examination of station no. 105 obtained by endoscopic ultrasound guided fine needle aspiration and a clinical diagnosis of Siewert type II esophagogastric junction adenocarcinoma of HER2-positive (T2N0M1) was made. This evidence concerns the gene ERBB2 and tubular adenocarcinoma.