Unlike Leptin, Adiponectin, an adipokine involved in energy homeostasis, is reduced in obesity (Kern et al., 2003) and possesses anti-inflammatory properties on macrophages (Ohashi et al., 2010; Ouchi et al., 2001; Qi et al., 2014). The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.