NOS2 and obesity due to melanocortin 4 receptor deficiency: As a consequence, NLRP3−/− and iNOS−/− animals are protected from obesity-related insulin resistance, macrophage infiltration, and extracellular matrix (ECM) deposition and are enriched in metabolically healthy adipocytes compared with WT mice (Becerril et al., 2018; Perreault and Marette, 2001; Stienstra et al., 2010).