During obesity, necrosis of adipocytes driven by hypertrophy is a prominent phagocytic stimulus that regulates ATM infiltration, which is gradually increased (Cinti et al., 2005), and macrophage–adipocyte interaction was proposed to aggravate meta-inflammation (Wellen and Hotamisligil, 2003; Fig. 2, A and B). This evidence concerns the gene ATM and obesity due to melanocortin 4 receptor deficiency.