Related disorders are observed in several organs, such as the pancreas (which regulates insulin secretion; de Oliveira et al., 2020), muscles (Pedersen and Febbraio, 2012), and the liver (Diehl, 2010), and obesity appears, therefore, to be a global condition rather than a tissue-specific disease (Gesmundo et al., 2021). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.