Furthermore, we assayed the effect of T-cM onto organoids derived from mouse colon (colonoids) and confirmed that T-cM also induced YAP activation and promoted proliferation in colonoids (Figure 4—figure supplement 1G–J), like in small intestinal organoids, consolidating the relevance of our findings to colon cancer. The gene discussed is YAP1; the disease is malignant colon neoplasm.