The coexistence of WT and mutant cells within emerging tumours has been the subject of recent interest: consistent with our results, paracrine communication between epithelial cells has been found to induce YAP pathway activation (Flanagan et al., 2021; Yum et al., 2021; van Neerven et al., 2021; Krotenberg Garcia et al., 2021). The gene discussed is YAP1; the disease is neoplasm.