On the other hand, cells derived from Apc mutant intestinal tumours generally grow as hyperproliferative and non-polarised hollow spheres or cysts (Drost et al., 2015; Sato et al., 2011; Jardé et al., 2013; Schwank et al., 2013; Germann et al., 2014; Onuma et al., 2013). This evidence concerns the gene APC and intestinal neoplasm.