IL6 and psoriasis: For example, C/EBPδ has been shown to play a role in the pathogenesis of psoriasis (Lan et al., 2020) and in acute inflammatory signaling by regulating COX-2 (Wadleigh et al., 2000), IL-6 (Litvak et al., 2009), and TLR4 (Balamurugan et al., 2013).