XBP1 and cancer: We further investigated the immunological characteristics of XBP1, XBP1 expression was negatively correlated with almost all immunological biomarkers and TILs in BC patients across human cancers, and the result was further validated using data from GSE25055, GSE25056 and TCGA dataset, which also indicated that XBP1 was negatively associated with immune-related processes, such as adaptive immune response, response to chemokines, and T cell activation, suggesting that XBP1 might have an immunosuppressive role in BC.