In breast cancer, expression level of XBP1 influences the sensitivity of breast cancer to tamoxifen, and XBP1 increased sensitivity to tamoxifen in human breast cancer cell xenografts [12], and tumour autoimmune-related DCs with high expression of XBP1 can suppress antitumour immunity and promote the occurrence, invasion and metastasis of breast cancer [9]. This evidence concerns the gene XBP1 and breast cancer.