To furtherly explore the clinically predictive value of NAC response of XBP1, ROC analysis was performed to assess the clinically predictive value of NAC response among XBP1 and other clinical characteristics (age, ER status, PR status, tumour size (cm), lymph node and histological grade), and the AUC value of XBP1 for NAC response was obviously greater than other clinical characteristics (Table 4). Here, XBP1 is linked to neoplasm.