Neuroinflammation plays a prominent role in the pathogenesis of vascular dementia26, 36 and the present results show the dysregulation of specific gene systems with a role microglial function and neurodegenerative disease, such as FTL, CXCR4 and C3.37, 38, 39. The gene discussed is CXCR4; the disease is neurodegenerative disease.