CXCL10 and heart failure: Intriguingly, serum concentration of CXCL10 is increased in the patients with advanced heart failure (Altara et al., 2016a; Safa et al., 2016; Wu et al., 2021), suggesting that CXCL10 production is closely associated with heart failure; however, it remains to be elucidated how CXCL10 expression is regulated in the failing heart.