Interestingly, a negative correlation was discovered between the level of ALKBH8 and urothelial cancer progression.12 Additionally, some recessive truncating mutations in human ALKBH8 gene were recently shown to cause intellectual disability associated with the absence of (S)-mchm5U, (R)-mchm5U, m5U, mcm5Um or mcm5s2U units in total tRNA.13 Here, ALKBH8 is linked to Intellectual disability.