FN1 and pancreatic neoplasm: Similarly to our findings, Raza et al. reported the effect of FN derived peptides on PANC-1 growth in 3D PEG-based hydrogels and showed that PANC-1 cells exhibited higher proliferation at the end of the culture in the FN enriched hydrogels compared to the FN-free gels.48 Additionally, Miyamoto et al. reported that pancreatic cancer cell lines growth was enhanced on FN coated 2D monolayers compared to the controls (uncoated surfaces) at the end of the culture.90 From the above studies in both 2D and 3D systems it is evident that FN stimuli promotes cell growth in vitro.