There are various factors that control bone remodeling including insulin-like growth factors (IGFs), tumor growth factor-beta (TGF-β), bone morphogenetic proteins (BMPs) and cytokines.1 Among the various inductive growth factors of bone morphogenetic proteins (BMPs) including kidney development, limb formation, angiogenesis, tissue fibrosis and tumor development, osteogenic differentiation is one of the well-known and notable regulating processes that involve BMP-2.2 It increases the number of mature OBs by enhancing the differentiation capability of various stem cells. This evidence concerns the gene CLN5 and neoplasm.