The β-galactoside is located in subsite C with its C3 substituent reaching into subsites A–B and its C1 substituent reaching into subsites D–E.2 Galectin-1 is involved in several biological processes, e.g. tumor progression, inducing angiogenesis, suppressing anti-tumor immune responses and metastasis, making it an interesting therapeutic target.3–5. The gene discussed is LGALS1; the disease is neoplasm.