AKR1A1 and breast cancer: Aldehydes or ketones are metabolized from hydrocarbons in the body with the help of activities of alcohol dehydrogenase (ADH) and cytochrome P450 enzymes.56 Phillips et al. related the elevation in the oxidative stress and enhanced activity of cytochrome P450 with BC pathology.57 The involvement of ADH, cytochrome P450 and oxidative stress in BC (in this case IDC) supports the fact that there is a conversion of hydrocarbons to alcohol.