Insulin plays a significant role in the metabolism of liver glycogen via the regulation of glycogenesis, which controls the above metabolism by standardizing the conversion of the dependent form of glucose-6-phosphate into the independent form of glucose-6-phosphate of glucose synthase.39 Glycogen synthetase enzyme increases glycogenesis, which plays a key role during the expansion of diabetes via converting glycogen into glucose, resulting also in boosting the blood glucose concentration. Here, INS is linked to diabetes mellitus.