Hexokinase, glucose-6-phosphatase and fructose-1-6-phosphate enzymes play key roles in the gluconeogenic pathway.44,45 Glucose-6-phosphatase and fructose-1-6-phosphate levels reach extended levels due to the boost in the synthesis of enzymes, which results in the upregulatation of glucose production via the liver during diabetes. This evidence concerns the gene G6PC1 and diabetes mellitus.