APP and Alzheimer disease: In support of a general function in preventing the aggregation of neurodegeneration-associated fragments, we found that BAG6 also interacts with and solubilizes the amyloidogenic Aβ peptide and the β-secretase generated C-terminal fragment of the amyloid precursor protein, βCTF, involved in AD pathology (Pulina et al., 2020; Checler et al., 2021).