One example is lncRNA ANRIL promotes Akt phosphorylation and activates mTOR signaling pathway, thereby elevating the expression of GLUT1 and LDHA (key enzyme to catalyze the conversion of pyruvate to lactate in the last step of aerobic glycolysis86, so as to increase glucose uptake, and rapidly generate ATP for proliferation of NPC cells ultimately87. This evidence concerns the gene CDKN2B-AS1 and nasopharyngeal carcinoma.