The Adenylate and uridylate (AU)-rich elements (AREs) in the 3 ́ regions of DANCR has strong binding ability with NF90/NF45 complex, and can interact directly with NF90/NF45 to stabilize HIF-1 α mRNA promoting NPC metastasis65. This evidence concerns the gene SETD2 and nasopharyngeal carcinoma.