The lncRNA PVT1 also serves as a scaffold for the chromatin modification factor KAT2A to mediate histone 3 lysine 9 acetylation (H3K9), thereby recruiting the nuclear receptor binding protein TIF1β to activate NF90 transcription, increasing HIF-1α stability and promoting a malignant phenotype of NPC cells39. The gene discussed is ILF3; the disease is nasopharyngeal carcinoma.