Mechanistically, up-regulated FAM225A functions as a competing endogenous RNA (ceRNA) for sponging miR-590-3p and miR-1275, leading to the upregulation of their target integrin subunit β 3 (ITGB3), and the activation of FAK/PI3K/Akt signaling to promote NPC cell proliferation and invasion21. Here, FAM225A is linked to nasopharyngeal carcinoma.