One example is lncRNA ANRIL promotes Akt phosphorylation and activates mTOR signaling pathway, thereby elevating the expression of GLUT1 and LDHA (key enzyme to catalyze the conversion of pyruvate to lactate in the last step of aerobic glycolysis86, so as to increase glucose uptake, and rapidly generate ATP for proliferation of NPC cells ultimately87. The gene discussed is LDHA; the disease is nasopharyngeal carcinoma.