A case in point is that lncRNA HCG18 modulates Wnt/β-catenin and Hedgehog pathway by directly binding to miR-140 and effectively act as a ceRNA for miR-140 to increase the expression of cyclin D1, which contributes to NPC progression55.The lncRNA ANRIL induces proliferation, inhibits apoptosis, and reduces radiosensitivity in NPC cells through sponging miR-125a56. The gene discussed is CDKN2B-AS1; the disease is nasopharyngeal carcinoma.