Accumulation of cellular acetyl-CoA promotes de novo lipid biosynthesis and histone H3K27 acetylation, which ultimately regulates the peptidyl arginine deiminase 1 (PADI1)-MAPK-MMP2/9 pathway, and then promoting NPC proliferation, metastasis and cisplatin resistance93. The gene discussed is PADI1; the disease is nasopharyngeal carcinoma.