A total of 2880 kinds of compounds were screened; of these, thevebioside, the active ingredient of Thevetia peruviana (Pers) K. Schum (TPKS), an ornamental shrub belonging to the Gentianales order, was identified to inhibit SRC3-mediated signaling by ubiquitination to induce NSCLC cell apoptosis 31. Here, NCOA3 is linked to non-small cell lung carcinoma.