Our results showed that the phosphorylation levels of IKKα/β, NF-κB, p65, IkBα, p38, JNK and ERK increased in a time-dependent manner after TNF-α (10 min and 30 min) stimulation in pancreatic cancer cells (MIA PaCa-2) (Fig. 4C). Here, CHUK is linked to familial pancreatic carcinoma.