BAX and neoplasm: Western blotting and IHC analyses of xenograft tumor tissues showed that Bax, a proapoptotic protein, was expressed at much higher levels in the shTRIM44 group than in the NC group, whereas the expression levels of the Bcl-2 were decreased, suggesting that TRIM44 knockdown promoted cisplatin-induced apoptosis and reversed chemoresistance (Figure 6F-G).