In acute myeloid leukemia (AML), RNA-binding protein YBX1 is required for survival of AML, and mechanistically, YBX1 can cooperate with IGF2BP1 and IGF2BP3 to increase the stability of c-MYC and BCL2 mRNA in an m6A dependent manner 191. The gene discussed is IGF2BP1; the disease is acute myeloid leukemia.