In renal cell cancer, transcription factor early growth response 2 (EGR2) increases the expressions of IGF2BPs, and IGF2BPs enhance the stability of sphingosine-1-phosphate receptor 3 (S1PR3) mRNA in m6A-dependent manner, and S1PR3 drives tumorigenesis and metastasis 190. This evidence concerns the gene S1PR3 and renal cell adenocarcinoma.