In esophageal squamous cell carcinoma (ESCC), LncRNA CCAT2 increases IGF2BP2 expression, and then IGF2BP2 improves mRNA stability of thymidine kinase 1 (TK1) in m6A modification manner, which promotes tumor progression 152. The gene discussed is IGF2BP2; the disease is esophageal squamous cell carcinoma.