In colorectal cancer patients, high expressed LINC00460 is correlated with poor overall survival, and mechanistically, LINC00460 interacts with IGF2BP2 to bind to the 3'UTR of high-mobility group AT-hook 1 (HMGA1), and enhances the stability of HMGA1 mRNA 150. Here, IGF2BP2 is linked to colorectal cancer.