In colon cancer, high expression of IGF2BP3 is associated with poorer overall survival, and IGF2BP3 recognizes and binds to the CDS region of Cyclin D1 to regulate cycle, and IGF2BP3 also regulates angiogenesis through m6A modification of vascular endothelial growth factor (VEGF) 176. Here, IGF2BP3 is linked to colonic neoplasm.