Therefore, the carcinogenesis model of ADC could be acquired by generation of organoid cultures with normal human cervical keratinocytes immortalized with ectopic TERT expression (HCK1T), which conditionally expressing the combination of HPV oncogenes (HPV16 E6E7 or HPV18 E6E7), genetic alterations commonly found in ADC and potential lineage-specifying factors (c-MYC, KRAST58A, FOXA2, SMAD4mi). The gene discussed is MYC; the disease is AIDS dementia complex.