Kaplan-Meier plots (www.kmplot.com/analysis/), which included 2032 cases from the GEO and TCGA databases, revealed that higher ZDHHC22 expression was associated with better relapse-free survival in BrCa patients, especially in ER-positive BrCa patients (Fig. 1D). This evidence concerns the gene ZDHHC22 and invasive breast carcinoma.