Such severe ER stress and ROS production induced by MHO7 facilitated the release of ICD-related DAMPs, which further induced ICD in vivo and mediated a robust antitumor immune response, as evidenced by the release of antitumor cytokines, the activation of mature DCs and high levels of CD8+ T cells but deceased Tregs, ultimately leading to the inhibition of tumor growth and metastasis. Here, CD8A is linked to neoplasm.