Glycolysis and β oxidation of fatty acids were key parts of metabolic programming, and our results showed that compared with 0 ng/ml LAMC1-induced 3T3-L1 CM, 100 ng/ml LAMC1 CM caused a reduced rate of extracellular acidification in gastric cancer and an increased rate of fatty acids oxidation (Fig. 4B-4C, Figure S3F-3G), moreover, oxygen consumption rates were also increasing in the 100 ng/ml LAMC1-induced 3T3-L1 CM coculture group (Fig. 4D, Figure S3H). The gene discussed is LAMC1; the disease is gastric cancer.