PITPNC1 and cancer: At present, with regard to the mechanism by which adipocytes promote cancer peritoneal metastasis, the most studied theories include the following four: (1) Adipocytes up-regulate CD3646, fatty acid binding protein 4 (FABP4)47 and Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) expression48 to accelerate fatty acids transport and oxidation in order to satisfy own energy requirement.