The ELISA results showed that LAMC1 in CM with STAT3 knockout was down-regulated (Fig. 5D, Figure S5A) and When STAT3-knockout gastric cancer cell CM to coculture with 3T3-L1 (Fig. 5E), the 3T3-L1 maintain the fibroblast phenotype in Oil Red O staining by decreasing the protein production of adipogenesis genes C/EBPα, PPARγ and Perilipin-1 and increasing DLK1 expression (Fig. 5F, Figure S5B), suggesting that STAT3 regulates the expression of LAMC1 in post-transcriptional level. The gene discussed is PLIN1; the disease is gastric cancer.