Meanwhile, palmitic acid could induce endoplasmic reticulum stress and promote tumor metastasis58, however, Lin's team59 had an opposite observation that palmitic acid impaired hepatocellular carcinoma development by inhibiting mTOR and STAT3 pathway activation which also contradicted our results that adipocyte-derived palmitic acid activated STAT3 in gastric cancer. This evidence concerns the gene STAT3 and hepatocellular carcinoma.