Chen K et al65 found that miR-193a-3p methylation silencing could target up-regulation of related genes GRB7, ERBB4, SOS2 and KRAS in the downstream of MAPK / ERK signaling cascades, resulting in the potent modulation of ovarian cancer invasion and metastasis, and its inhibitory effect on KRAS also had a potential role in reducing circulating tumor cells in the blood66. The gene discussed is SOS2; the disease is ovarian cancer.