On the other hand, some evidence has been found that the anti-inflammatory effects of andrographolide are related to regulation of the immune system19 and that andrographolide suppresses TLR4 expression and NF-κB signaling in multiple myeloma cells.20 Multi-targeting andrographolide and its analogs have potential use in the prevention and treatment of metabolic syndrome21 and stroke22via the NF-κB signaling pathway. This evidence concerns the gene NFKB1 and AL amyloidosis.