LAMP2 and acute myeloid leukemia: We found that after chronic ethanol consumption, SIRT1 up-regulation via SalA increased LAMP-2 and RAB7 protein levels in AML-12 cells; however, SIRT1 knockdown notably inhibited this increase, suggesting that autophagosome–lysosome fusion promoted by SalA was mostly abrogated in the presence of SIRT1 siRNA (Fig. 5a).