It is used in the synthesis of lipophilic aldehydes to inhibit human gastric lipase (HGL) and pancreatic lipase (HPL) and function as potent anti-obesity drugs.15 Additionally, it is used in the synthesis of the macrolide core of migrastatin, an anti-cancer drug.16 Thus, both (R)-BGE and the (S)-diol product have significant pharmaceutical relevance. The gene discussed is LIPF; the disease is obesity due to melanocortin 4 receptor deficiency.