KDM1A and neoplasm: The results of RNAi-mediated knockdown or pharmacological inhibition of LSD1 seem to suggest that this enzyme induces re-expression of epigenetically silenced tumor suppressor genes and regulates p53 transcriptional activity or down-regulation of several leukemic-related genes.15–17 Overall, LSD1 represents a promising target for the treatment of leukemia as well as other solid tumors.