SESN2 and peripheral arterial disease: In recent years, it was reported that unacylated ghrelin, another form of ghrelin, could also regulate miR-221/222 expression to reduce ischemia-induced tissue damage in a mouse model of peripheral artery disease.42 Whether unacylated ghrelin protects cells from Ang II insult via miR-122/Sesn2 pathway and the indispensability of the n-octanoylated serine 3 residue in this process still need more investigation.