The encoded proteins are called stress-inducible proteins, since they can protect cells against various insults such as oxidative stress and DNA damage.30 In cardiovascular diseases, Sesn2 exerts cytoprotective effects in energetic stress-induced cell death, Ang II-induced endothelial toxicity, and myocardial ischemia,31–33 all of which can result in heart failure. Here, SESN2 is linked to cardiovascular disorder.