INS and Hyperglycemia: Chronic oral administration of β-Caryophyllene reduces glyceamia, depressive-like behavior and neuropathic pain in streptozotocin (STZ)-induced diabetic mice [9].In addition, recently, it has been elucidated that β-Caryophyllene effectively protects β-cells by alleviating hyperglycemia through increasing insulin release, and also ameliorate oxidative stress and inflammation in pancreatic tissue of experimentaldiabetic rats [10].