SGK1 and Familial prostate cancer: For example, an exploration in prostate cancer revealed that SGK1 knockdown repressed cell growth, metastasis, and EMT in prostate cancer cells.26 Another study in lung adenocarcinoma implied that SGK1 facilitated cell migration and invasion mediated by miR-576-3p.27 In the present research, SGK1 was highly expressed in CRC and verified as a target of miR-383-5p.