Nifu is a potent inhibitor of STAT3 and has been previously used to treat acute diarrhea.21 In recent years, it was also found to be effective against cancer23 and to alleviate diabetes-induced kidney damage by inhibiting NF-κB activation, oxidative stress, and apoptosis.24 However, no study on its effects on glycolipid metabolism and the related mechanisms was reported. Here, STAT3 is linked to diabetes mellitus.