INS and Disorder of lipid metabolism: In contrast, the STAT3 signaling also stimulates the expression of lipogenic genes and promotes the de novo synthesis of fatty acids by increasing the expression of hepatic olfactory regulatory element binding protein-1c (SREBP-1c).14 Finally, STAT3 signaling increases hepatic gluconeogenesis by increasing the expression of key enzymes involved in gluconeogenesis and reduces insulin sensitivity by inhibiting the phosphorylation of PI3K and AKT in the liver.15 Therefore, this signaling molecule could be an important therapeutic target for glucose and lipid metabolic disorders.