DY and RZ also could significantly inhibit the Wnt pathway in CRC cell line, HT29, which might be resulted from their down-regulation of Wnt-related genes such as LPAR6, PRICKLE4, ASPM, MYB, FGF19 and STAT1. All in all, our findings suggest that DY and might be a good resource of Wnt inhibitors. Here, PRICKLE4 is linked to colorectal carcinoma.